Bone Marrow Transplant. 2026 Aug 20. doi: 10.1038/s41409-026-03014-9. Online ahead of print.
Quentin Neven, Julie Berbis, Gérard Michel, Carine Domenech, Cécile Pochon, Sandrine Visentin, Cécile Renard, André Baruchel1, Mony Fahd, Virginie Gandemer, Marilyne Poirée, Charlotte Jubert, Stéphane Ducassou, Catherine Paillard, Laura Olivier-Gougenheim, Alexandre Theron, Corinne Armari-Alla, Justyna Kanold, Sandrine Thouvenin-Doulet, Mathilde Veneziano Broccia, Caroline Thomas, Marie-Dominique Tabone, Guy Leverger, Pascal Auquier, Jean-Hugues Dalle, Paul Saultier.
Abstract
Total body irradiation (TBI)-based conditioning is the standard regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in high-risk or relapsed pediatric acute lymphoblastic leukemia (ALL), but is variably used before age 4 because of concerns about long-term toxicity. Long-term physical, educational, and quality-of-life outcomes were assessed in patients from the French long-term follow-up program LEA who underwent TBI-based HSCT for ALL at 2 to